Somatotropin is currently one of the best drugs for prolonged muscle building. While this is the only drug that makes you forget about the bad genetic inheritance. Injection of growth hormone is always a risk because some phenomena are not reversible. But, despite the risk of possible side effects, it remains one of the most favorite drugs in athletes. Growth hormone is surrounded by a mystery aura in its application. Some call it a miracle tool, which in the shortest time gives a gigantic increase in strength and mass. Others consider it completely useless in achieving sports results and explain this by the fact that the drug stimulates the growth of only “dwarfs”: children who are lagging behind in physical development. Some think that growth hormones cause in adults terrible deformities of bones in the form of the Habsburg jaw and giant growth. Also there is complete confusion: how to apply growth hormones and in what dosage? Disagreements about hormones are so complex that the reader must have some initial basic information in order to understand the essence of the problem.
Growth hormone is a polypeptide consisting of 191 amino acids. It is produced by the human pituitary gland and is secreted with appropriate stimuli (for example, training, sleep, stress, low blood sugar). And here it is important to understand that the released human growth hormone does not directly affect the body itself, but only stimulates the production in the liver and subsequent release of insulin-like growth factors and somatomedins into the blood. They also have different effects on the body. The only problem is that the liver can produce a limited amount of these substances, so that the effect of these substances on the body is limited. If hormones are injected from the outside, they only excite the liver to produce and release these substances into the bloodstream and do not, as mentioned above, have direct effects.
Until the mid-80’s there was only an active human form as an exogenous source of administration. It was extracted from the pituitary gland of the deceased, which was extremely costly. When in 1985. the intake of human growth hormone began to be associated with the extremely rare disease of Jakob Kraufalda (brain disease), which faded with dementia and death, then some, but not all manufacturers began to withdraw the drug from production. Fortunately, science did not doze and created a synthetic hormone growth, which is produced by genetic engineering from transformed muscle cells. And here it is sold in many countries.
The use of growth hormone has a threefold effect on the athlete in the field of his achievements. First, the growth hormone has a strong anabolic effect, which contributes to the intensive synthesis of proteins, which is expressed in muscle hypertrophy (increase in the size of the muscle cell) and in muscle hyperplasia (an increase in their number). The effect of hyperplasia is extremely interesting, because Steroids do not give it. This is probably the reason why the growth hormone is called the strongest anabolic hormone. Secondly, the growth hormone has a strong effect on the fat burning process. He intensely turns fat into energy, which leads to an intensive disappearance, and this allows the athlete to consume more calories. Thirdly, what often remains unnoticed is that the growth hormone strengthens the connective tissue, tendons, bones and cartilage, and this is probably one of the main reasons for the incredible increase in strength that is observed in some athletes. Athletes of bodybuilding and powerlifting say that the growth hormone protects, thanks to this quality, athletes from damage, if the simultaneous reception of steroids, the force is growing rapidly.
The question of the correct dosage and duration of administration is difficult to answer. Because there have been no scientific studies on the effect of growth hormone on athletes, so here you can only come from experience. In pituitary insufficiency of growth, caused by the lack or insufficient release of growth hormones by the pituitary gland, manufacturers advise: a weekly dose of an average of 0.6 m / kg body weight. Those. A 100kg athlete would have to receive 60me weekly in injections. In this case, the dose would be divided into 3 intramuscular injections for 20me within a week. Another way to take: subcutaneous injections, which must be administered daily, most often 8m per day. Top-athletes who have enough money are accepted daily 4-8. Because the growth hormone has a half-life of less than an hour, then many athletes share their daily dose by 2-3 small subcutaneous injections at 2m. The introduction of regular small doses is considered more effective. On that there are reasons. As we know, the growth hormone stimulates the liver to produce and release somatomedins and insulin-like factors that cause the desired effects in the body. Because the liver can produce only a limited amount of these two substances, one can doubt that with large injections the liver is able to produce immediately the appropriate amount of somatomedins and insulin-like growth factors. Therefore, the liver responds better to frequent and small doses. Who introduces a solution of growth hormone in the same place, notice that the site of injection is the disappearance of adipose tissue. Therefore, the site of the injection should be constantly changed to avoid local lipotrophy (the disappearance of adipose tissue). For several years, it turned out that the action of the growth hormone strongly depends on the dosage. This means the following: either stock up on the money and take it right, or you just throw money away.
The effective dose is 4-8m per day. For comparison: the pituitary gland of a healthy adult daily releases 0.5-1.5 mm of growth hormones. Duration of admission is often dependent on the financial capabilities of the athlete. Judging by experience, the growth hormone is taken most often from at least 6 weeks to several months.
It is interesting that the effect of the hormone does not decrease after several weeks, therefore, at the same dosage, permanent increments are achieved. Bodybuilding athletes who have a positive experience with the use of growth hormone, say that the accumulated strength and, especially, the musculature mostly remain after the end of the hormone intake. American doctor Dr. William N. Taylor confirms this in his book “Anabolic steroids and athletes,” where you can read: “The statements of athletes that the achieved strength and weight after the end of hormone intake persist means an increase in the number of muscle cells (hyperplasia). Essences, strength and muscles can grow further after months, because through training the muscle hypertrophy stimulated by them is transferred to newly acquired muscle cells. ”
The undesirable effect of growth hormones, the so-called side effects, is a very interesting topic, which provokes heated discussions. First of all, it should be said that the growth hormone causes side effects that are not similar to those observed with anabolic / androgenic steroids, such as: decreased testosterone production, acne, hair loss, aggressiveness, increased levels of estrogen, a phenomenon of virilization in women , enhanced water-salt retention, etc.
To start with – a little chemistry.
Growth hormone is a hormone polypeptide, consisting of 191 amino acids. It is produced by the human pituitary gland and is secreted with appropriate stimuli (for example: training, stress, sleep, irritation, low blood sugar). It is important to understand that the resulting growth hormone does not have a direct effect on the body, but only stimulates the release of insulin-like growth factors and somatomedins into the blood, which are taken for granted. The problem is that the liver can only produce a limited amount of these substances. And if hormones are injected from the outside, they only induce the liver to produce and release these substances without exposing the body to direct effects.
Until the mid-80’s there was only natural human growth hormone, which was extracted from the pituitary gland of deceased people. You understand, this procedure was incredibly expensive. When in 1985 the intake of human growth hormone began to be associated with the extremely rare disease of Jakob Kraufeld (brain disease), which led to dementia and death, manufacturers began to withdraw the drug from production. Today, almost no human growth hormone for injections is being sold (the exception is Lithuanian “Somatotropin”). Fortunately, science did not doze off and invented synthetic growth hormone, which is produced with the help of genetic engineering and transformed muscle cells. Today artificial growth hormone is sold in many countries under different trade names: Humatrop, Norditropin, Somatosorm, Somatogen, etc.
How does growth hormone work?
In fact, it has three effects on the body. Firstly, it has a strong anabolic effect and promotes an increased synthesis of proteins, which is expressed in muscle hypertrophy (increase in the size of the muscle cell) and in muscle hyperplasia-an increase in their QUANTITY. The last property of growth hormone is unique in that anabolic steroids do not give a similar effect. This is probably the reason why the growth hormone is called the strongest anabolic hormone. Secondly, the growth hormone has a strong effect on the fat burning process. He intensively burns fat, which allows the athlete to consume more calories. Thirdly, which is often overlooked, the growth hormone strengthens the connective tissue, tendons, bones and cartilages, which, apparently, is one of the main reasons for the incredible increase in strength that is observed in some athletes. Some bodybuilders and lifters are convinced that in this way, growth hormone protects them from injuries, the likelihood of which increases dramatically in parallel with the growth of the working weights accompanying the taking of steroids. In addition, the increase in bones, cartilage, tendons and internal organs makes the athlete REALLY MASSIVE. And this is not the mass that “leaves”, as it happens, when the user “peels” off steroids.
True, some athletes, having tried growth hormone, did not feel any positive changes. Why did this happen?
1. The dosage of the drug was too low and / or it was not applied long enough. These problems are understandable, since growth hormone is very expensive.
2. Growth hormone was used alone. The fact is that when a somatotropic hormone is taken, the body’s need for a hormone of the thyroid gland, insulin, corticosteroids, gonadotropins, estrogens, and steroids increases dramatically. Therefore, if growth hormone is taken alone, the effect of its effect is significantly reduced. In fact, in order for the body to be in the optimal anabolic state, three hormones are needed: a somatotropic hormone, a thyroid hormone L3 (cytomel), and insulin. Only in this case the liver is able to produce a sufficient number of somatomedins and insulin-like growth factors. This anabolic state can be further enhanced by the use of drugs with pronounced anti-catabolic properties, for example, clenbuterol. However, those who are going to combine the intake of growth hormone with clenbuterol or ephedrine, should know that these drugs reduce the level of production of the body of insulin and the hormone L3. A similar decline occurs when the athlete sits on a rigid pre-competitive diet.
3. Instead of a real growth hormone, you are slipped a fake or a substandard drug. Few people know how this drug really should look like what the “black market” dealers use. In the pharmacy, you are unlikely to get it. At least, without a prescription. As for the low quality of the drug, it is known that the growth hormone should be stored in a cool place, otherwise it begins to decompose. Therefore, if the bottle says that it contains 4,000 International units of growth hormone, there is no guarantee that they are not 3000 or 2000.
SIDE EFFECTS OF GROWTH HORMONE – Rich Piana
How to take growth hormone? In what dosage? How long?
These questions are difficult to answer, as there have been no laboratory studies on this subject. Here you can only rely on the experience of athletes familiar with this thing. In pituitary insufficiency of growth, caused by the absence or low release of growth hormones by the pituitary gland, manufacturers recommend a weekly intake of 60 IU per kg of body weight. Thus, an athlete weighing about 100 kg should introduce himself an order of 6000 IU of growth hormone. At the dose of 6000 IU, it is desirable to divide into three doses of 2000 IU. Another option is hypodermic injections, which should be administered daily, approximately 8,000 IU per day. The average dosage of top athletes varies around 4000-8000 IU of growth hormone per day. Since the half-life of growth hormone is less than an hour, many athletes prefer to divide the daily dose into two parts, which are administered in the morning on an empty stomach and in the evening before bedtime – this time is considered optimal. In addition, since the liver is able to produce insulin-like growth factors and somatidene in a limited amount, it simply can not absorb a large dose of exogenous growth hormone, which again speaks for the fractional administration of this drug.
Although some bodybuilders swear that they have achieved amazing results, taking only 2,000 IU of growth hormone a day, if you are serious about working with this drug, you should stock up a decent amount of money to count on 4000 IU per day. Growth hormone should either be taken in large quantities, or not taken at all, since in a small dosage it will simply not work, as discussed above.
As for the duration of the course, it should be at least six weeks and may last several months. It is believed that the risk of side effects increases if the duration of admission is six months. It is interesting that the effect of the hormone does not diminish after several weeks after the start of the admission, so it is useless to increase the dosage, as is customary in the case of steroids.
The positive properties of growth hormone also consist in the fact that the strengths and volumes of muscles achieved with its help, as a rule, do not decrease after the end of the course. This is connected, as already mentioned, with the increase in the number of muscle cells. Due to this, many athletes manage to progress many months after the end of reception of a growth hormone.
Another interesting property of growth hormone is that frequent injections of it into one and the same place can lead to burning in this place of the fat layer. Therefore, it makes sense to inject the drug into different parts of the body.
I would like to talk a little about how the somatotropic hormone interacts with insulin. In principle, not too advanced athletes are not recommended to supplement the intake of growth hormone injected from outside with insulin – it is sufficient to eat fully every 3 hours. Thus, you will maintain the level of insulin at a sufficiently high level. In addition, it should be noted that too much insulin will make you fat, because excess insulin activates certain enzymes that convert glucose to glycerol, and then to triglycerol. With the other on the other hand, too low a level of insulin in the blood, which often occurs during the “drying” before the competition, dramatically reduces the effect of growth hormone on the body. The ideal option would be to find a doctor who would do you blood sugar and urine tests and determine how much insulin you need.