An aromatase inhibitor, structurally similar to natural steroid hormone androstenedione.
In postmenopausal women, estrogens are produced primarily by conversion of androgens to estrogens by the enzyme aromatase in peripheral tissues. The mechanism of action is due to irreversible binding eksemestana active fragment aromatase, which leads to enzyme inactivation.
Exemestane has no progestogenic and estrogenic activity. When applying only slight androgenic activity manifests itself in high doses. It has no effect on the biosynthesis of cortisol and aldosterone in the adrenal glands.
The slight increase in levels of LH and FSH in the serum observed even at low doses exemestane. This effect, however, is not typical for preparations of this pharmacological group. He probably developed on the basis of feedback at the pituitary level: reducing the concentration of estrogen stimulates the secretion of gonadotropins in the pituitary gland and also in postmenopausal women.
The use of exemestane (Exemestane):
If used for prophylaxis to prevent side effects during a severe course, it is sufficient to half a pill every day or one tablet (25mg) after 1-2days.
If side effects are apparent, you should take one pill every day until the disappearance of side effects.
Receiving exercise after ingestion.
AROMASIN (exemestane) side effects.
Side effects Aromasin may occur frequently and in varying degrees. For example, an athlete can face such unpleasant consequences, such as:
– increased sweating
– dizziness, headache,
– skin rash,
– insomnia and others.
One athlete side effects may occur rapidly and the other use of the drug can take place painlessly. It all depends on individual sensitivity of man to the active ingredient of the drug. But usually, at the recommended dosage, side effects AROMASIN not occur at all or occur to a small extent.