Methandienone is a drug previously used to accelerate the healing of burns, as well as to increase the overall health of women, but soon Methane (slang name of the drug) gained popularity among bodybuilders seeking to increase their muscle mass.
This drug has different names, for example, Dianabol, Danabol, Nerobol, etc.
Pharmacological action – anabolic, hematopoietic.
Penetrating into the cell nucleus, it activates the genetic apparatus of the cell, which leads to an increase in the synthesis of DNA, RNA and structural proteins, activation of tissue respiration chain enzymes and enhancement of tissue respiration, oxidative phosphorylation, ATP synthesis, and accumulation of macroerges within the cell. Stimulates anabolic and suppresses catabolic processes caused by glucocorticoids. It leads to an increase in muscle mass, a decrease in fat deposits and a negative nitrogen balance. Hematopoietic action is associated with an increase in the synthesis of erythropoietin. The antiallergic effect is due to an increase in the C1 concentration of the inhibitor complementary fraction and a decrease in the contents of the C2 and C4 complement fractions. Androgenic activity (low) can promote the development of secondary sex characteristics in the male type.
Quickly and completely absorbed from the digestive tract, low bioavailability due to the presence of the effect of “first passage” through the liver. In the blood with specific globulin-vectors binds to 90%. It is subject to the final biotransformation in the liver with the formation of inactive metabolites. Excreted by the kidneys. The duration of the action is up to 14 hours.
How to take Dianabol?
- For newbies. The first is to consult with a specialist, since Methandienone is a potent drug that, for the unprepared organism can be a severe blow and bring not very pleasant consequences. It is recommended to choose the lighter anabolics. But if you decide to still use this steroid, you should do it in moderation, parallel to supporting the body with drugs that reduce the effects of steroids, particularly in the liver.
- For experienced bodibildirov. There is a well-known athletes in circles method “pyramid”, where the dose of the drug is constantly increasing. This method is effective only at first, because after the body gets used to the amount of substance used, and stops taking pills, stopping their action. Steroids should be the size of pre-read the recommendations in the instructions to the drug.