Steroids, in a general sense, are hormones chemically legit steroids derived from cholesterol. In total, two large groups legit steroids websites of steroids can be distinguished: sex steroids (hormones) and corticosteroids (hormones of the adrenal cortex). The hormones of the adrenal cortex have a very different nature of action, and most of them are intended for the survival of the organism in a stressful situation. So, cortisol relieves inflammation and stimulates the destruction of tissues to get energy from them, and adrenaline in a stressful situation stimulates blood flow to the muscles and brain, clears consciousness, raises blood sugar levels, increases strength and endurance.
Simplified, sex hormones always have as their composition two components – anabolic and androgenic or feminizing.
Androgenic action – strengthening of the masculinity – is the property of the hormone to cause and strengthen secondary male sexual characteristics: increased sebum production legit steroids websites, and as a result, acne, dandruff, baldness, hypertrophy of the prostate, increased libido and potency, increased sense of domination and aggressiveness. These properties are inherent only in male sex hormones. In women, this effect is called virilization (the development of secondary sexual characteristics in women in the male type).
The feminizing effect is due to the estrogenic or progestogenic activity of the steroid hormone. It is manifested by an increase in the size of the mammary glands, acceleration of body fat gain, water retention, increased appetite, calming effect on the nervous system, which causes some lethargy.
Anabolic action is the main reason for which steroids are used in sports. It manifests itself in:
- Increase protein synthesis in cells legit steroids websites;
- Accelerate the synthesis and increase the accumulation of glycogen in the muscles;
- Retention of fluid in tissues;
- Strengthening the work of the immune system;
Strengthening the absorption and accumulation of vitamins and minerals from food.
It is because of the anabolic effect that anabolic steroids help to build muscle more and faster, accelerate the healing of injuries, make a person stronger and more enduring.
Androgenic-anabolic steroids (hereinafter – AAS), as pharmacological drugs, are the male sex hormone testosterone or its derivatives, obtained with the aim of enhancing the anabolic and weakening of the androgenic effect of testosterone. However, many AAS have also estrogenic and / or progestagenic activity, since they are partially converted into female sex hormones, or their configuration is similar to that.
The mechanism of the effect of steroids on cells
Any hormone affects the cell through a special receptor designed for this hormone or a group of similar hormones. Receptor, in fact, is a complex protein machine that is triggered when a certain hormone joins it and sends a signal to the nucleus or other cellular organelles through substances – secondary mediators or transmembrane ion currents, after which the hormone, having done its work, detaches and swims further. On the bloodstream. Receptors of steroid hormones and thyroid hormones are inside the cell. On the surface of the membrane are receptors of peptide hormones, of which more than two thousand are known.
By introducing artificial hormones, you thereby increase their concentration in the body. Even at the lowest dosages, the concentration becomes 2-3 times higher than the physiological one. By doing this, you increase the likelihood of meeting the hormone with the androgen receptor and, accordingly, more often stimulate the nucleus to synthesize certain proteins. Also legit steroids websites, the parameter has a value, such as the steroid’s ability to stabilize the androgen receptor. The more it is, the longer the hormone starts the processes of anabolism in the cell.
However, the effect rises almost linearly only to a certain limit, after which even doubling the dosage will add only 10-20% to the useful effect (protein synthesis).
For example, 3000 mg of testosterone per week will not increase you any more significantly more muscle than 1200 mg, but the side effects will increase very much, because they are due to non-anabolic activity, and partial conversion into female sex hormones. Thus, it makes no sense to take mega-dose, but it is much more productive and safer to use low and medium dosages. But to take longer courses. And also create conditions under which even the minimum dosage of AAS will work effectively.