Effects of anabolic steroids

Effects of anabolic steroids

We will try to explain to you, quite easily, the effect of anabolic steroids on the athlete’s body, the whole truth, as it really is.

This article is designed to protect people from deceitful information spreading on the Internet, on TV or elsewhere, about anabolic steroids.

Anabolic steroids are synthetic derivatives of testosterone, the male sex hormone, possessing both anabolic and androgenic action simultaneously, therefore, sometimes they are called anabolic-androgenic steroids (AAS).

The androgenic effect carries the negative side of testosterone, that is, all the side effects such as the development of secondary sexual characteristics, aggression, low voice, sexual attraction, the development of genital organs, and hairiness are associated with it. The anabolic effect of steroids is associated with an increase in muscle mass, that is, activation of muscle growth due to the synthesis of proteins in muscle cells.

The history of the discovery of anabolic steroids

effects of steroidsIn the first, anabolic steroid was obtained by the German biochemist Adolf Butenandt in 1931, he managed to extract 15 mg of androstenone from 10,000 l of urine.

A little later, Nazi Germany, the Netherlands and Switzerland, combining their efforts in the field of obtaining anabolic steroids, extracts from the extract of testicles an animal more powerful component, crystalline testosterone.

During the military operations in Germany, anabolic steroids were experimenting with prisoners, as are rumors that Hitler used steroids in the form of injections, according to his personal doctor. According to unconfirmed reports, the Nazis used steroids for aggression, and increased the endurance of soldiers. Other countries used AAS to restore the health of soldiers who were released from captivity.

Since 1940, steroids have begun to enter actively into the sporting life of the society, for example, the success of the USSR national weightlifting team made the US team doctor actively cooperate with chemists, in order to obtain an anabolic steroid that had minimal androgenic activity, while at the same time maximizing anabolic action , as a result, methandrostenolone was obtained. In 1956, the Directorate for Supervision of Medicines and Food Products (FDA) fully endorses the legal use of the new drug. First of all, methandrostenolone was released for tissue regeneration and regeneration in the post-burn period, as well as for pensioners, instead this steroid begins to be widely used in bodybuilding and other power sports, and in large, uncontrolled doses. As a result, mass infertility begins, and prostate hypertrophy in athletes. In 1976, the International Olympic Committee (IOC) prohibits the use of any anabolic steroids, and from this moment begins the era of hunting for athletes using so-called doping. As you can see, the thoughtless, unjustified, absolutely uncontrolled use of anabolic-androgenic steroids has led to disastrous consequences, and as a consequence, the contamination of any mention of potent drugs such as steroids.

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Basic Aspects of Understanding Anabolic Steroids

If you use testosterone in its natural form, it will quickly start to be excreted from the body, due to the fact that the half-life in the body is only 10 minutes. In addition, every ten minutes, exactly half of what is left will be excreted from the body, and after one hour nothing will remain, as you see the use of testosterone in its natural form is extremely ineffective. You can certainly put an injection into the muscle, which will lead to an increase in the duration of testosterone on the body, exactly nine hours, but this is not enough to feel at least some effect on the body. Therefore, before the scientists, the task was set to make testosterone, so that it could effectively act on orgasm. The solution to this problem was ingenious, chemists created derivatives of testosterone molecules, 17-alpha-alkylate and 1-methyl (to prevent destruction in the liver, thus making the use of steroids orally, as tablets), 17-beta ether (injection , is soluble in fats, thus accumulating in tissues, as a consequence, the duration of action is increased to two months). Thus, to date, absolutely all steroids differ only in the variation of the above derivatives of the testosterone molecule.

Underestimated androgenic properties, overestimated androgenic effect and low anabolic effect, or overestimated anabolic and androgenic action, this is what distinguishes the derivatives of the testosterone molecule, from the original substance of testosterone, which explains the different side effect, the spectrum of action, and of course the different effectiveness from the use of all existing anabolic steroids.

Anabolic and androgenic steroids are two different things, but they used to be considered vice versa. People wanted to create such a drug, which would have only anabolic benefit to athletes, without any side effects, androgenic. Now everyone understands that any steroid has an anabolic and androgenic effect on the body, only in different tissues. At the present time conditionally qualify all steroids for anabolic and androgenic, that is, steroids in which the androgenic action against testosterone is underestimated is called anabolic, where it is higher, is called androgenic.

A similar effect on the body, from the use of anabolic-androgenic steroids is associated with their common ancestor, testosterone. Consideration of all the biochemical processes occurring in the body with the use of steroids does not make sense for bodybuilding, so consider only those moments that the athlete needs to know for more competent use of AAS.

The mechanism of action of steroids

The mechanism of action of steroidsSteroids are taken by injection, that is, intramuscularly directly into the blood, taken orally in tablet form Steroids go through the gastrointestinal tract to the liver, where they are completely or partially destroyed, or enter the bloodstream in its original condition.

Having got into the blood of a steroid, in the form of steroid molecules, spreads throughout the bloodstream of a person. The purpose of the steroid molecule is to convey the information to the cells needed. The cells intended for this purpose have on the outer membrane, various receptors. The so-called steroid receptors in large quantities are contained in muscle cells. The steroid molecule is attached to the steroid receptor, skipping all other types of receptors, and vice versa, other non-steroid receptors are looking for a “necessary” molecule. When connected to the steroid receptor, steroid molecule is capable of transmitting the information of the muscle cell, but the problem is that in most of the body, about 98% of steroid molecules are bonded globulin that binds sex hormones, and only 1-2% of steroid molecules are free state, which can form a so-called steroid-receptor complex.

The steroid molecule, in conjunction with the steroid receptor, is sent to the nucleus of the muscle cell, where it joins the DNA nucleic acid segments. That is, an imprint is made with DNA (transcription). Thus, a ribonucleic acid is created that begins to leave the cell nucleus, entering the cytoplasm, it joins the RNA located here, where the protein (proteins) from the amino acids on the RNA information matrix is ​​synthesized, using ribosomes (translation). So, not in a tricky way, in combination with training in the gym, muscle hypertrophy, muscle cell growth occurs.

In addition, steroid molecules have an anti-catabolic effect, they block the cortisol receptors located on the membrane, minimizing the percentage of destruction of proteins in the muscle cell.

Due to steroids, the synthesis of creatine phosphate (CF) increases, and as you know, it plays a crucial role in the recovery of adenosine triphosphate (ATP), and this means accumulation of energy in the muscle cell. If needed, ATP passes to ADP (adenosine diphosphate) releasing a huge amount of energy, which explains the increase in strength, but not mass, for example, when used, oxandrolone (a large amount of CF in the muscle cell is synthesized). The increase in endurance from the use of steroids is explained by the fact that in the muscle cell there is an increased supply of carbohydrates in the form of glycogen, in addition there is still an increased accumulation of fluid, as a result, the volume of muscles increases.

The percentage of fat in the body is lost, while maintaining muscle mass and hardness of muscles is increased due to the fact that steroids reduce endogenous insulin, i.e. muscle cell is less dependent on insulin, and now it could metabolize the carbohydrates in the form of glycogen and protein form of amino acids.

Steroid pampus, as if the muscles pump blood with a pump, another positive effect of using steroids. The number of erythrocytes and blood volume increases muscle like balloons, blood flows more, and along with it and nutrients received together with the blood to the muscles becomes greater in connection with the body begins to be supplied with much better oxygen, so for example the effect of using runners sprint distances.

After the steroid-receptor complex has its purpose in the cell nucleus, the steroid molecule back into the bloodstream, and repeats the above-mentioned steroid cycle again, or converted into an unnecessary, having exhausted all its resources steroid molecule and appears in the urine.

Why steroids act differently on different people

The fact is that once in the blood, the steroid molecule does not immediately bind to the globulin, or is in a free, active state. Part of the steroid molecules, in the process of metabolism, can be used by the body, and then withdraw from it, and some can generally go into female sex hormones – estrogens (the phenomenon is called aromatization), with the help of enzymes (enzymes), part can go dihydrotestosterone (DHT ). It is noteworthy that dihydrotestosterone is chemically more strongly bound to muscle receptors, in contrast to testosterone, while it has a stronger, binding potential with sebaceous glands and hair follicles. Experts agree that dihydrotestosterone has a stronger steroid effect, besides DHT is not converted into estrogens.

Effects of anabolic steroidsIn any case, the spent anabolic steroids will be excreted from the body with urine.

For example, some steroids have more free steroid molecules in their arsenal that last longer in a free state, and as a result they have a better chance of finding the right steroid receptor, such drugs include Deco, Dianabol, Sustanon-250, Parabolan, Cypionate.

That is, it turns out that the more a person has free receptors in muscle cells, the more there will be the effect of steroids on the body, since free steroid molecules will have much more chances to unite into a steroid-receptor complex with a free receptor in the muscle cell.

At the age of 20 our receptors reach the peak of their activity, steroids are at the maximum level of digestibility, so it is more appropriate at this age to use anabolic steroids in order to increase muscle mass, strength and relief. But before crossing this line, natural training and training on anabolic steroids, it is necessary to take into account a lot of nuances, starting from strength indicators, ending with the expediency of their application.

It is not possible within the framework of this article to consider all those little things that form the basis for understanding anabolic steroids, but the necessary minimum that every self-respecting athlete must know.

This information about steroids was provided only for informational purposes, do not treat it as an instruction for the use of AAS. It is much more correct to protect you from a mistaken understanding of anabolic steroids.